Living Organisms
Medchemexpress LLC ANTS | 5398-34-5 | 99.1% | 100 MG
ANTS is a fluorescent dye utilized for measuring membrane leakage. It has an excitation wavelength of 380 nm and an emission wavelength of 520 nm. When encapsulated in liposomes with DPX, ANTS provides an effective method for assessing membrane permeability.
- Solid appearance, white to off-white color.
- Store at 4°C, protected from light.
- When in solvent, store at -80°C for 6 months or -20°C for 1 month, protected from light.
- Soluble in DMSO at 20 mg/mL (46.80 mM) with ultrasonic, warming, and heating to 80°C.
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A broad-spectrum cephalosporin antibiotic; inhibits the growth of S. aureus (MIC50 = 0.26 UG/ml), as well as P. aeruginosa, E. coli, and H. influenzae (MIC50s = 1, 0.06, and 0.01 UG/ml, respectively); increases survival in mouse models of infection with strains of S. aureus (ED50s = 3.5 and 8.3 mg/kg) and E. coli (ED50s = 0.5-25 mg/kg)
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An inhibitor of neutrophil elastase (IC50 = 44 nM for the human enzyme); selective for neutrophil elastase over trypsin, thrombin, plasmin, kallikrein, chymotrypsin, and cathepsin G at 100 µM; decreases LPS-induced NF-κB nuclear translocation in isolated rat PMVECs at 50 mM; reduces pulmonary edema, increases in the number of MPO-positive cells in the lung tissue, and the severity of lung injury in a rat model of LPS-induced acute lung injury at 10 mg/kg
Cayman Chemical Cefepime hydrochloride hydra
A cephalosporin antibiotic; inhibits the growth of some clinical isolates of Corynebacterium, Streptococcus, and Staphylococcus (MIC90s = 0.03-8 μg/ml); inhibits the growth of some Citrobacter, Enterobacter, Klebsiella, Salmonella, Serratia, Shigella, and enteric bacilli species in addition to P. mirabilis and E. coli clinical isolates (MIC90s = ≤0.12-2 μg/ml); inhibits the growth of pneumococci strains (MICs = 0.5-2 mg/l) in vitro and in vivo in a mouse model of peritonitis (ED50s = 0.6-1.14 mg/kg)
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A muscarinic acetylcholine receptor antagonist (Ki = 15 nM for the rat receptor); inhibits bovine AChE by 43% at 10 µM and BChE (IC50 = 1.6 µM for the horse enzyme) in cell-free assays; reduces the proliferation of P388 and P388/ADR leukemia cells (EC50s = 10 and 12 µM, respectively); induces apoptosis in BT474 and MDA-MB-231 cancer cells at 15 µM and induces autophagy in the same cells at 10 µM; decreases tumor weight and volume and improves survival in an MDA-MB-231 breast cancer mouse xenograft model at 1 mg/kg three times per week
Cayman Chemical PemetrexedodIM salt hydra 50mg
An antifolate with anticancer activity; an inhibitor of thymidylate synthase and dihydrofolate reductase (Kis = 109 and 7 nM, respectively); has increased potency for thymidylate kinase when polyglutaminated (Ki = 1.3 nM); an inhibitor of glycinamide ribonucleotide formyltransferase (Kis = 9,300 and 65 nM for the non-glutaminated and polyglutaminated enzyme) and aminoimidazole carboxamide ribonucleotide formyltransferase (Kis = 3,600 and 265 nM for the non-glutaminated and polyglutaminated, respectively); inhibits proliferation of CCRF-CEM cells but not 5,10-dideazatetrahydrofolate-resistant CR15 cells (IC50s = 0.254 and 200 µM, respectively); reduces tumor growth in A549, H1299, and PC-9 NSCLC mouse xenograft models but not in models using the same cell lines overexpressing thymidylate kinase
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A selective inhibitor of G9a histone methyltransferase (IC50 = 1.7 μM); less effectively inhibits G9a-like protein (GLP; IC50 = 38 μM) and has no effect on other known histone methyltransferases
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A cephalosporin antibiotic; inhibits the growth of some clinical isolates of Corynebacterium, Streptococcus, and Staphylococcus (MIC90s = 0.03-8 μg/ml); inhibits the growth of some Citrobacter, Enterobacter, Klebsiella, Salmonella, Serratia, Shigella, and enteric bacilli species in addition to P. mirabilis and E. coli clinical isolates (MIC90s = ≤0.12-2 μg/ml); inhibits the growth of pneumococci strains (MICs = 0.5-2 mg/l) in vitro and in vivo in a mouse model of peritonitis (ED50s = 0.6-1.14 mg/kg)
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A cephalosporin antibiotic; active against 45 isolates of P. aeruginosa (MIC90 = 3.1 UG/ml) and acts synergistically against P. aeruginosa isolates when combined with gentamicin, tobramycin, amikacin, or mezlocillin; binds to P. aeruginosa PBP1a, PBP1b, and PBP3 but not PBP2, PBP4, or PBP5; increases survival in mice infected with various P. aeruginosa strains (ED50s = 1.93-137 mg/kg for all)